Ken‐ichi Tanaka, M. Yasuda
Sep 18, 1998
Citations
0
Influential Citations
23
Citations
Journal
Tetrahedron-asymmetry
Abstract
Abstract A novel and practical synthesis of ( R )-3-chlorostyrene oxide (−)- 1 was achieved starting from commercially available 3-chloroethylbenzene 3 . Enantiopure (−)-3-chlorostyrene bromohydrin (−)- 5 was obtained by the treatment of racemic (±)- 5 with lipase QL in the presence of acylating reagents. 3-Chloro-α,β-dibromoethylbenzene 4 , a precursor of (±)- 5 , was synthesized via the expeditious bromination of 3 which was developed by these authors.