A. Jalilian, M. Binehshmarvasti, P. Kumar
Sep 1, 2006
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Quality indicators
Journal
Pharmaceutical Chemistry Journal
Abstract
The synthesis of seven 99mTc-labeled nitrophenol radiosensitizers (N2OS chelates) was undertaken for evaluating their in vitro biostabilty as possible hypoxia tumor imaging agents. The title compounds (2–7) were successively synthesized, characterized, and finally radiolabeled (99mTc-NaTcO4, stannous chloride, pH 10) to obtain the new complexes (8a–8f) for evaluation. The purity and stability of complexes (in human and rat serum) were evaluated by chromatographic methods (radio-TLC, ITLC, HPLC). The most stable complex (over 6 h) was 99mTc-labeled 3-[3′-N-(2″-hydroxy-5″-nitrobenzylamino)-2′-propanol]-1-(4′-methyl)thiourea (8e). Biodistribution studies of 8e in mammary tumor-bearing rats are in progress.