A. Horti, A. Koren, H. Ravert
Apr 1, 1998
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0
Influential Citations
48
Citations
Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
The radiochemical synthesis of 2-[18F]fluoro-3-(2(S)-azetidinylmethoxy)pyridine (2-[18F]A-85380, [18F]1) was accomplished by Kryptofix® 222 assisted nucleophilic no-carrier-added [18F]fluorination of 2-iodo-3((1-tert-butoxycarbonyl-2(S)-azetidinyl)methoxy)pyridine, 2 followed by acidic deprotection. The average radiochemical yield was 10% and the average specific radioactivity was 1050 mCi/μmol, calculated at end-of-synthesis (EOS). © 1998 John Wiley & Sons, Ltd.