J. Musachio, W. B. Mathews, H. Ravert
1994
Citations
0
Influential Citations
9
Citations
Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
(+)-N-[11C]-Benzyl-N-normetazocine (1S,5S,9S-(+)-cis-2-[11C]-benzyl-2′-hydroxy-5,9-dimethyl-6,7-benzomorphan), a potent and selective ligand for the σ receptor, was prepared by N-benzylation of (+)-cis-N-normetazocine with [α-11C]-benzyl iodide in ethanol using sodium hydrogen carbonate as the proton acceptor. The radiotracer was purified by semi-preparative reverse-phase HPLC. The average specific activity was 746 mCi/μmol calculated at end-of-synthesis (EOS). The average time of synthesis including formulation was 35 minutes.