G. Hartman, R. D. Hartman
Jul 1, 1983
Citations
0
Influential Citations
7
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
The synthesis of 5, 6-dichloro-3-nitropyrazinamine has been carried out by decarboxylative nitration of 5, 6-dichloro-3-nitropyrazine-2-carboxylic acid. The nitro heterocycle was found to undergo a variety of reactions, which include nucleophilic displacement of the 6-chloro group by amines, acetylation of the free amino group with acetyl chloride, bromo-deamination with isoamylnitrite in bromoform, as well as the formation of imidazolo and triazolo condensed ring systems.