R. Brown, M. Joseph, T. Leigh
1977
Citations
0
Influential Citations
4
Citations
Journal
Journal of the Chemical Society. Perkin transactions 1
Abstract
7,8-Dihydro-8-methylpterin (3) has been prepared by reduction of [2-amino-5-(p-chlorophenylazo)-6-hydroxypyrimidin-4-yl(methyl)amino]acetaldehyde (7; X = N2C6H4Cl) and by reduction of the corresponding 5-nitro-pyrimidine. The addition of nucleophilic reagents to the dihydropterin is reported and further reactions with the products are described. In a new purine synthesis the 5-nitropyrimidine (7; X = NO2) is cyclised to 9-methyl-guanine 7-oxide (26) with sodium hydroxide. The latter undergoes typical N-oxide reactions and has been used for the synthesis of other purine derivatives.