T. Miyamoto, H. Egawa, K. Shibamori
Sep 1, 1987
Citations
0
Influential Citations
19
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
1-Cyclopropyl- and 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid derivatives having a sulfinyl or sulfonyl group at C-7 were synthesized from 2,6-dichloro-5-fluoronicotinic acid derivatives by the route involving the Dieckmann-type cyclization. The displacement reactions of these compounds with pyrrolidine and piperidine gave mainly the 7-(1-pyrrolidinyl)- and 7-(1-piperidinyl)-1,8-naphthyridine derivatives 24-27, respectively. Enoxacin, a potent antibacterial agent, was also synthesized with the analogous route.