D. Briel, T. Franz, B. Dobner
Sep 1, 2002
Citations
0
Influential Citations
6
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
The synthesis of 6-methylsulfanyl-2,4-dithioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile 4 is described. Compound 4 was reacted with various alkylants. The reaction with chloroacetic acid derivatives results in the formation of thieno[2,3-d]pyrimidines 8. When methyl iodide was used 2,4,6-tris(methylsul-fanyl)pyrimidine-5-carbonitrile 5 was obtained. The substitution of the methylsulfanyl groups in compound 5 by several N-nuclophiles leads to amino substituted pyrimidines.