S. El-Sakka, M. Soliman, R. S. Abdullah
Oct 1, 2013
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Journal
International Journal on Environmental Sciences
Abstract
A series of novel 2-aminothiazole derivatives (3a-e) has been synthesized by the reaction of 4-[4- methoxy-3-methylphenyl]-4-oxobutenoic acid (1) with thiourea derivatives (2a-e). The thiazolopyridazine derivatives (4a-c) and (5) were obtained from the reaction of 4-hydroxy-1,3-thiazole (3a-e) with hydrazine and phenylhydrazine, respectively. The behavior of the 4-hydroxy-1,3-thiazole (3a-e) toward acetic anhydride and bromine was also studied. The proposed structures of the products were based on microanalytical and spectroscopic data.