K. Hrnčariková, D. Végh
Jul 1, 2003
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Influential Citations
11
Citations
Journal
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Abstract
We present 1-pentafluorophenyl-1H-pyrrole and some of its electrophilic substitution reactions: formylation and acetylations. The 2-substituted products formed in these reactions are selectively and in high yield converted into 3-substituted products by treatment with trifluoromethanesulfonic acid. A general synthesis of 3-acylpyrroles was developed by the trifluoromethanesulfonic acid–mediated rearrangement of the corresponding 2-acylpyrroles.