A. Aleksandrov, M. Elchaninov, D. A. Tishina
Apr 1, 2021
Citations
0
Influential Citations
0
Citations
Journal
Russian Journal of Organic Chemistry
Abstract
Abstract Acylation of 1,3-benzothiazol-6-amine with furan-2-carbonyl chloride in propan-2-ol gave N -(1,3-benzothiazol-6-yl)furan-2-carboxamide which was converted to the corresponding thioamide by treatment with excess P 2 S 5 in anhydrous toluene. The subsequent oxidation with potassium hexacyanoferrate(III) in alkaline medium afforded 2-(furan-2-yl)benzo[1,2- d :4,3- d ′]bis[1,3]thiazole which was subjected to electrophilic substitution reactions (bromination, nitration, hydroxymethylation, formylation, acylation). The substituent entered exclusively into the 5-position of the furan ring.