Xu Qian-qian
2010
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Journal
Qilu Pharmaceutical Affairs
Abstract
OBJECTIVE To study the synthesis of the compound 1-[3α-(acetoxy)-17β-hydroxy-2β-(morpholin-4-yl)-5α-androstan-16β-yl]-1-(prop-2-enyl)pyrrolidinium bromide(related substance D).METHODS The compound(2β,3α,5α,16α,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)-5α-androstan-3α,17-diol-3-actes was synthesized by using 2α,3α,16α,17α-diepoxy-17b-acetoxy-5a-androstane as the starting material via the ring-opening,reduction,ring-opening,acylation reactions,and then separated and purification resolution 3 type optical isomer by column chromatograph.The compound 1-[3α-(acetoxy)-17β-hydroxy-2β-(morpholin-4-yl)-5α-androstan-16β-yl]-1-(prop-2-enyl) pyrrolidinium bromide(related substance D) was synthesized with via catalytic reaction and allyl group brom reaction.RESULTS The structure was identified by 1H-NMR and LC-MS.CONCLUSION The related substance D of Rocuronium Bromide can be synthesized by this method,and provide related substances reference standards for controlling the product quality.