Chu Qing-song, Huang Kun, Li Wei
2016
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Journal
Chinese Journal of Medicinal Chemistry
Abstract
In order to perform the quality control of trelagliptin succinate,three related substances were synthesized.Firstly,related substance A was synthesized from 1-methylbarbituric acid via chlorination and substitution.Then,related substance B was obtained by condensation and substitution from related substance A.Finally related substance B undergoes one step reaction to give related substance C.The synthetic route and reaction conditions were mild and simple operation.The target compounds can be used as the reference substances in the quality control of trelagliptin succinate and their detailed data was reported for the first time.