Zhao We
2014
Citations
0
Influential Citations
0
Citations
Journal
Coal and Chemical Industry
Abstract
A new synthesis method of repaglinide industrialization was studied. 4- Carboxymethyl- 2- ethoxy benzoic acid ester reacted with pivaloyl chloride toform active intermediate, then by one pot method,2-oxethyl-4-{2-{[(1S)-3- methyl-1-[2-(1- piperidyl) phenyl] butyl]amino}-2- oxygen generation ethyl} ethyl benzoate was synthesized from(S)-3- methyl-1-[2-(1-piperidyl) penyl] butylamine, the target compound was synthesized by the hydrolysis of repaglinide. The results showed that the new synthesis method of repaglinide had higher purity,higher yield which was up to 63%,a mild reaction condition,convenient operation,friendly environment,and was suitable to large scale manufacturing.