Chen Li-gong
2007
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Journal
Journal of Jilin Institute of Chemical Technology
Abstract
2-bromothiophene was synthesized respectively by three methods: acetic acid solvent,carbon tetrachloride solvent and direct bromination.A series of factors such as the style of adding bromine,time of adding bromine,the ratio of materials and the reaction temperature were investigated,which affected the yields of 2-bromothiophene in the direct bromination.And the economic performance of the three production process was compared.Experimental results indicate that the methods of glacical acetic acid and carbon tetrachloride as solvent are not suitable for industry,but the direct bromination method is the best one.When bromine was added as gas into thiophene,the yield of 2-bromothiophene is higher and there was little by-product.Meanwhile,the key factors effecting on the yield of 2-bromothiophene are the adding time of vaporizing bromine and whether it was warmed-up or not.The optimum conditions of direct bromination are: the ratio of materials is 0.55∶1 to 0.6∶1,the reaction temperature is 65 to 75 ℃,and the adding time of bromine is 6 to 8 h.