H. Fujisawa, Tomoya Fujiwara, Y. Takéuchi
May 1, 2005
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0
Influential Citations
19
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Journal
Chemical & pharmaceutical bulletin
Abstract
We report the synthesis of optically active 2-aryl-2-fluoropropionic acids 2 as non-epimerizable mimics of 2-arylpropionic acids 1, a class of compounds which have been widely used as non-steroidal anti-inflammatory drugs (NSAIDs). This is a continuation of our research involving the design, synthesis, and evaluation of chiral fluorine-containing organic molecules as effective analogues of pharmacologically important compounds.