Yulin Hu, H. Ziffer
May 1, 1990
Citations
0
Influential Citations
8
Citations
Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
The synthesis of 2-amino-3-([15N]-methylamino)propanoic acid (synonyms, BMAA, β-N-methylamino-alanine) from α-acetamidoacrylic acid and [15N]-methylamine is described. Enantioselective hydrolysis of the acetamide group, mediated by the enzyme Acylase 1 (EC 3.5.1.14), yielded (R)-BMAA and the (S)-α-acetamido derivative. Acid hydrolysis of the latter compound yielded (S)-BMAA.