T. Shimizu, T. Masuda, K. Hiramoto
2000
Citations
0
Influential Citations
8
Citations
Journal
Organic letters
Abstract
The stereoselective total synthesis of reveromycin A (1), a potent inhibitor of eukaryotic cell growth, has been accomplished on the basis of the stereocontrolled construction of the 6,6-spiroketal system, efficient succinylation of the tert-alcohol under high pressure, and the introduction of the unsaturated side chains.