P. Gallagher, T. A. Hicks, A. Lightfoot
Jan 10, 1994
Citations
0
Influential Citations
11
Citations
Journal
Tetrahedron Letters
Abstract
Abstract A novel synthesis of Rhein ( 2 ), the active metabolite of the anti-osteoarthritic drug Diacetyl Rhein ( 1 ) has been acehived. Key steps include stereospecific olefination of aldehyde 21 with novel phosphonate 28 and the cyclisation of acid 31 to produce anthracene 32 .