L. Lang
2009
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Journal
Chinese Journal of Pharmaceuticals
Abstract
p-Hydroxypropiophenone, which was synthesized from phenol and propionyl chloride by esterification and Fries rearrangement reaction, reacted with CuBr2 to obtain α-bromo-p-hydroxypropiophenone, followed by the condensation with p-hydroxyphenethylamine in THF and reduction with KBH4 to give ritodrine. The overall yield was about 39%.