D. Yong
2011
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Journal
Strait Pharmaceutical Journal
Abstract
OBJIECTIVE To prepare of rocuronium bromide.METHODS Rocuronium bromide was synthesized from 2β-(4-morpholinyl)-16β-(1-pyrrolidinyl)-3α,17β-diol-5α-androstan by acetylation,selective hydrolysis to afford 2β-(4-morpholinyl)-16β-(1-pyrrolidinyl)-5α-androstan-3α,17β-diol 17-acetate,and finally quaternary ammonium with allyl bromide.RESULTS AND CONCLUTION The chemical structures of rocuronium bromide and its intermediantes were confirmed by 1H-NMR,13C-NMR,ESI-MS.The total yield is 59.6%.