Tang Yan-feng
2012
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Journal
Journal of Nantong University
Abstract
4-(benzyloxy)-1H-indazole(VI) is synthesized via five-step reaction: hydrogenation,acetylation,nucleophilic substitution,diazotization and aminolysis by using the 2-methyl-3-nitrophenol(Ⅰ) as starting materials.And the total yield is 76.3%.The structure of the aim compound is characterized by FTIR、1H NMR and ESI-MS.In this paper,the synthesis procedure of 1-(4-(benzyloxy)-1H-indazol-1-yl)ethanone(Ⅴ) is investigated in detail.The results show that the yield is 87.1% when the molar ratio of isoamyl nitrite to N-(3-(benzyloxy)-2-methylphenyl)acetamide(Ⅳ) is 1.6∶1,the reaction temperature is 90 ℃,and the reaction time is 16 h.This synthesis route is easy to handle and has high yield.