M. F. El-Behairy, E. Sundby
Mar 31, 2013
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Influential Citations
9
Citations
Journal
Tetrahedron-asymmetry
Abstract
Abstract The enantiopure (ee >99%) antiepileptic ( R )-(+)-Stiripentol has been stereoselectively synthesized via cross metathesis of 5-vinylbenzo[ d ][1,3]dioxole 1 and ( R )-(+)-4,4-dimethylpent-1-en-3-ol ( R )-(+)- 2 . A novel one-pot two-step pathway for the synthesis of 5-vinylbenzo[ d ][1,3]dioxole 1 starting from 3,4-dihydroxycinnamic acid has been introduced. A lipase catalyzed kinetic resolution access to enantiopure ( R )-(+)-4,4-dimethylpent-1-en-3-ol ( R )-(+)- 2 (ee >99%) has also been developed.