Shen Run-pu
2011
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Journal
Chinese Journal of Pharmaceuticals
Abstract
2,6,6-Trimethyl-1-cyclohexen-1-aldehyde underwent Wittig-Horner condensation with(3-methoxy-2-methylallyl)phosphonic acid diethyl ester to obtain 1-methoxy-2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1,3-butadiene,which was subjected to hydrolysis catalyzed by acid to obtain 2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-butenal,the key intermediate of vitamin A.The overall yield was about 47%.