Santosh K. Singh, Narendra Manne, M. Pal
Jun 12, 2008
Citations
0
Influential Citations
18
Citations
Journal
Beilstein Journal of Organic Chemistry
Abstract
An alternative and practical synthesis of (S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile was achieved. Reaction of L-proline with chloroacetyl chloride was followed by conversion of the carboxylic acid moiety of the resulting N-acylated product into the carbonitrile via the corresponding amide intermediate. The synthesized pyrrolidine derivative was utilized to prepare DPP-IV inhibitor Vildagliptin.