Yang Jia-li
2015
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Journal
Chinese Journal of Synthetic Chemistry
Abstract
A key intermediate,trifluoromethyl substituted( S)-tert-butylsulfonylamide( 3),was prepared by addition reaction of 2-methylindole with α-trifluoromethylaldimine under basic condition.The yield and stereoselectivity of 3 were 95% and 99 /1.( S)-2,2,2-trifluoro-1-( 2-methyl-1H-indol-1-yl) ethanamine( 4) with yield of 97% was synthesized by removing of the protection group of 3. The structure was confirmed by1 H NMR,13 C NMR,19 F NMR,FT-IR,EI-MS and HR-EI-MS.