R. Chinchilla, C. Nájera, S. García‐Granda
Sep 3, 1993
Citations
0
Influential Citations
16
Citations
Journal
Tetrahedron Letters
Abstract
The reaction of (2 S )- N -benzoyl-2- tert -butyl-4-methylene-1,3-oxazolidin-5-one ( 9 ) with isopropylidene-triphenylphosphorane at room temperature gives the corresponding cis and trans spirocyclopropane derivatives 10 in ca. 1:1 ratio. After separation of both diastereomers, by recrystallization and flash chromatography, and further acid hydrolysis, enantiomerically pure ( R )- and ( S )-2,3-methanovaline 11 are obtained.