M. Langlois, C. Meyer, J. Soulier
Sep 23, 2006
Citations
0
Influential Citations
8
Citations
Journal
Synthetic Communications
Abstract
Abstract The synthesis of (R) and (S)-3-amino quinuclidine, an important building block for the synthesis of chiral 5-HT3 serotonin receptor antagonists, is described. The key reaction is the reduction by NaBH4 of the imine prepared from the 3-quinuclidinone and chiral (S) or (R)-1-phenethylamine.