Ding Xiu-li
2008
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Journal
Applied Chemical Industry
Abstract
Ethyl 4-chloro-(S)-3-hydroxybutyrate was used as the starting materials to give(S)-3-hydroxytetrahydrofuran which was synthesized by the process of deoxidization and cyclization.The optimum temperature and time of the deoxidization were 40 ℃ and 4 h.The optimum temperature and time of the cyclization were 80 ℃ and 20 h.The chemical structures of the target compound and the intermediate were identified by element analysis,IR,NMR and MS spectra.The total yield and the purity of the product were 75.2% and 99.3%,the optical purity was 96.3%.