Zhou Yawen
2004
Citations
0
Influential Citations
0
Citations
Journal
Fine chemicals
Abstract
(S)-2-Amino-4-(methylthio)butyramide(Ⅰ) was prepared by reaction of methyl (S)-2-amino-4-(methylthio)butyrate hydrochloride with saturated ammonia solution in 63% yield.Reaction of Ⅰ with hydrochloric acid in methanol gave (S)-2-amino-4-(methylthio)butanamide hydrochloride(Ⅱ) in 66% yield.Ⅱ reacted with 4-chlorobutyryl chloride catalyzed by tetrabutylammonium bromide(TBAB) and potassium hydroxide in dichloromethane to afford (S)-4-(methylthio)-2-(2-oxopyrrolidin-1-yl)butyramide in 61% yield.Structures of the products were identified by TLC,IR and~1HNMR.