M. Bernier, E. Escher
Jul 9, 1980
Citations
0
Influential Citations
6
Citations
Journal
Helvetica Chimica Acta
Abstract
The synthesis of [Sar1, Val5, (4′-azido-3′,5′-ditritio)Phe8] angiotensin II from a iodinated precursor peptide is described. The principal problems of this synthesis and their resolution are discussed: (i) The β-induced autophotolysis of the highly tritiated (73 Ci/mmol) and photosensitive label, and (ii) the absorption problems encountered during the purification of microgramm quantities. Such photoaffinity labels are being used for specific labeling and isolation of peptide hormone receptors.