M. Zaidlewicz, A. Tafelska-Kaczmarek, A. Prewysz-Kwinto
Jun 20, 2003
Citations
0
Influential Citations
16
Citations
Journal
Tetrahedron-asymmetry
Abstract
Abstract Asymmetric synthesis of ( S )-bufuralol of 87% ee from 3-ethyl-2-hydroxybenzaldehyde, via the reduction of 2-bromo-1-(7-ethylbenzofuran-2-yl)ethanone with (−)- B -chlorodiisopinocampheylborane as the key step, followed by cyclization of the product bromohydrin to the corresponding epoxide and treatment with tert -butylamine, is described. ( S )-1-(3-Phenethylbenzofuran-2-yl)-2-propylaminoethanol of 73% ee, a propafenone analogue, was prepared following the same approach.