Chengxiang Shang, Chuanfang Zhao, Pengpeng Nie
Jul 2, 2021
Citations
0
Influential Citations
2
Citations
Journal
Tetrahedron
Abstract
Abstract A short and scalable approach toward the total synthesis of schaftoside, a naturally occurring bioactive C-glycosylflavone, has been developed from readily available (±)-naringenin. The highlights of this work are double Lewis acid promoted O→C rearrangement to form C-glycoside, oxidative dehydrogenation to construct flavone ring, and easy operational process to make the target product in multigram-scale.