Nitin Kumar, S. Drabu, K. Shalini
Feb 1, 2017
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Influential Citations
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Quality indicators
Journal
Arabian Journal of Chemistry
Abstract
Abstract A new series of 4, 6-substituted di-(phenyl) pyrimidin-2-amine ( IIa–d ) were synthesized by reacting chalcone derivatives with guanidine hydrochloride in the presence of dimethylformamide. The synthesized compounds were characterized by spectral analysis and were screened for anti-inflammatory activity. Two compounds 4-(4-nitrophenyl)-6-phenylpyrimidine-2-amine (IIa) and 4-(4-methoxyphenyl)-6-phenylpyrimidine-2-amine (IIb) showed highly significant reduction in oedema volume