A. Manikrao, R. Fursule, K. Rajesh
Dec 1, 2010
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Journal
Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry
Abstract
3-Mereapto-(4H)-2.2.4-triazole has been synthesized from 1-formylthiosemiearbazide. Different N-substituted β-chloropropionatnides have been prepared by reacting substituted amines with β-chloropropionylchloride. Different N-substituted β-chloropropionamides have been condensed with 3-mereapto-(4H)-1.2.4-triaxole in basic medium to obtain various 3-(N-substituted carboxamidoethylthio)-(4H)-1.2.4-triazoles. The structure of the synthesized compounds are confirmed by IR. 1 H NMR spectra and elemental analysis. All the compounds have been screened for their analgesic, anti-inflammatory and anxiolytic activity.