N. A. Pulina, V. Y. Kozhukhar’, A. S. Kuznetsov
Dec 9, 2017
Citations
0
Influential Citations
10
Citations
Journal
Russian Chemical Bulletin
Abstract
New 4-aryl-2-(4-arylamino)-1-(piperazin-1-yl)but-2-ene-1,4-diones and 2-{[2-(3-R-adamantan-1-yl)-2-oxoethylidene]hydrazinyl}-4-(het)aryl-4-oxobut-2-enoic acids were synthesized and used to obtain water-soluble compounds. Their influence on the blood coagulation system was studied, which revealed compounds with a high hemostatic activity and a low acute toxicity. A relationship between structure and pharmacological effect of the synthesized compounds was established.