Wu Yin, A. Middle
2001
Citations
0
Influential Citations
0
Citations
Journal
Chinese Journal of Medicinal Chemistry
Abstract
Moxonidine is known as the central hypotensor of the secondary generation.It was synthesized from acetamidine hydrochloride as the starting material via cyclization,nitration,chlorination,reduction,addition and dehydration,alcoholysis and salt formation.The overal yield was 24 8%.The yield of chlorination was 92 8%,using phosphorus oxychloride as the chlorinating agent.The yield of reduction was 87 7%,using iron powder as the reducting agent and steam distillation as the separation method.