K. Akira, H. Hasegawa, S. Baba
Sep 1, 1995
Citations
0
Influential Citations
9
Citations
Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
The synthesis of [4-13C]benzoic acid (BA) labelled in a single protonated carbon, for use as a probe to measure glycine conjugation activity by nuclear magnetic resonance (NMR) spectroscopy, has been reported. The labelled compound was prepared by a seven-step synthetic scheme on a relatively small scale using [2-13C]acetone as the source of label in overall yield of 16 %. The usefulness of [4-13C]BA was demonstrated by the NMR spectroscopic monitoring of urinary excretion of [4-13C]hippuric acid in the rat administered with the labelled BA.