G. Cignarella, S. Villa, D. Barlocco
1994
Citations
0
Influential Citations
10
Citations
Journal
European Journal of Medicinal Chemistry
Abstract
Abstract A new series of substituted 2,7-diazaspiro[3.5]nonan-1-ones (1a-I), structurally related to the muscarinic agonist RS-86, has been synthesized and tested for cholinergic properties both in vitro and in vivo. None of the compounds showed significant cholinergic properties at either the central or peripheral level. A possible explanation for the lack of activity is given.