E. Clair, F. H. Clarke, W. Edmiston
Nov 1, 1950
Citations
0
Influential Citations
2
Citations
Journal
Canadian journal of research
Abstract
2-Cyclohexanone acetic acid ethyl ester oxime was hydrogenated in acidic medium to the corresponding amino ester, which is of the cis form, as by ring closure it gives a hexahydrooxindole which in turn is reduced by lithium aluminum hydride to cis-octahydroindole. Also, it has been shown that the amino ester can be transformed into cis-aminoethylcyclohexane. The high pressure Raney nickel hydrogenation of the oxime ester followed by lithium aluminum hydride reduction gave also cis-octahydroindole, although in neutral medium the trans form could have been expected.