M. Gharpure, R. Choudhary, V. Ingle
Jun 19, 2013
Citations
0
Influential Citations
22
Citations
Journal
Journal of Chemical Sciences
Abstract
Abstract3-Hydroxy-2-aryl/heteroaryl-4H-chromones 4(a–n) were synthesized from appropriate chalcones 3(a–n) and acetylated to afford the corresponding acetoxy derivatives 5(a–n). All compounds were evaluated for antimicrobial activity against Staphylococus aureus, Bacillus subtillis, Escherichia coli and Pseudomonas aeruginosa as well as fungi e.g., Candida albicans and Aspergius niger. Inhibition caused by hydroxy flavones was relatively low, whereas that of their acetoxy ester analogues was substantially high. Structure of 6-chloro-2-(furan-2-yl)-4-oxo-4H-chromen-3-yl acetate (5j) was also supported by means of single crystal X-ray diffraction. Graphical AbstractAn effective microwave-assisted synthesis of 3-acetoxy-2-aryl/heteroaryl-4Hchromones 5a-n has been achieved through a series of reactions starting from phenols. These compounds have been screened against gram (+) ve and (-) ve bacteria. The acetoxy flavones were biologically more active than the corresponding hydroxyflavones.