Kuktae Kwon, Jung‐Ah Shin, Hee‐Yoon Lee
Dec 30, 2011
Citations
0
Influential Citations
9
Citations
Journal
Tetrahedron
Abstract
Abstract A short and facile synthesis of ( S )-felodipine was developed starting from ( R )-glycidol as the source of the chiral auxiliary. 2-Hydroxyethyl esters were found to undergo selective transesterification reactions in the presence of other esters. This selective transesterification reaction was applied to the synthesis of ( S )-felodipine through selective substitution of the 2-hydroxyethyl group possessing chiral ester with sodium methoxide.