Zhang Ming-guang
2007
Citations
0
Influential Citations
0
Citations
Journal
Modern Chemical Industry
Abstract
(S)-(+)-glycidyl tosylate,an important medicinal intermediate,is synthesized from(R)-(-)-3-chloro-1,2-propanediol,which is one of the side products produced in the process of preparing(S)-(+)-epichlorohydrin by hydrolytic kinetic resolution of(±)-epichlorohydrin.The side product obtained from the kinetic resolution of racemic(±)-epichlorohydrin is finely fractionated to cut a fraction of(R)-(-)-3-chloro-1,2-propanediol,and it is further cyclized into(S)-(+)-glycidol under the basic condition.(S)-(+)-glycidyl tosylate is obtained by esterifying(S)-(+)-glycidol with p-toluenesulfonyl chloride.Under optimal conditions the yield of product can reach 73%.