Yang Shijing
2013
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Journal
Chinese Journal of Pharmaceuticals
Abstract
5-Trifluoromethyl-3-(4-methyl-1H-imidazol-1-yl)aniline,the intermediate for antitumor agent nilotinib,was synthesized from 3,5-dinitro-1-trifluoromethylbenzene(2) by fluorination with tetramethyl ammonium fluoride to give 3-fluoro-5-trifluoromethyl-nitrobenzene,which was subjected to substitution with 4-methyl-1H-imidazole and reduction with an overall yield of about 50%.