Q. Lu, Haoming Tang, Y. Shao
Feb 1, 2008
Citations
1
Influential Citations
8
Citations
Journal
Chinese Chemical Letters
Abstract
A short and convergent approach for the synthesis of shikalkin (dl-shikonin) is presented. Stobbe reaction was employed to construct the aromatic skeleton 6. This is followed by a practical method to prepare the key epoxides 9 from aldehydes 8 in high yield. Finally, shikalkin is achieved by Grignard reaction and oxidation.