Xu Jing-xia
2011
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Journal
Anhui Medical and Pharmaceutical Journal
Abstract
Aim To explore the synthesis and structural identification of side chain acid.Methods The important intermediate for cephalosporin,2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino) acetic acid was synthesized by the methods of alkylation,oximate,cyclization and hydrolyzation using cyano acetamide as raw material.Results The yields of the four steps were 73.2%,66.3%,62.5% and 33.3%,respectively.The overall yield was 10.1%.Conclusion It's a better process with simple procedure,good yield.The structure was identified by elemental analysis,IR and NMR.