H. Hamamoto, V. Mamedov, M. Kitamoto
Nov 17, 2000
Citations
0
Influential Citations
36
Citations
Journal
Tetrahedron-asymmetry
Abstract
Abstract Reduction of methyl 3-chloro-2-oxo-3-phenylpropanoate with various reducing agents gave syn - and anti -3-chloro-2-hydroxy-3-phenylpropanoates 3 , which underwent an efficient lipase-catalyzed resolution. All four diastereomers were subsequently converted to N -benzoyl-(2 R ,3 S )-3-phenylisoserine methyl ester, C-13 side chain analogues of paclitaxel (Taxol).