M. I. Attia, N. El‐Brollosy, A. Kansoh
May 26, 2014
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0
Influential Citations
8
Citations
Journal
Journal of Chemistry
Abstract
Synthesis, X-ray structure and antimicrobial activity of 6-(1,3-benzodioxol-5-ylmethyl)-5-ethyl-2-{[2-(morpholin-4-yl)ethyl]sulfanyl}pyrimidin-4(3H)-one (8) are reported. Compound 8 exhibited activity towards S. aureus with MIC value of 0.0619 μmol/mL while it showed activity towards B. subtilis, B. cereus, C. albicans, and A. niger with MIC = 0.1859 μmol/mL. Single crystal X-ray structure of the title compound 8 confirmed its S-alkylation. The title compound crystallizes in the triclinic, -1, (5) A, (5) A, (9) A, (2)°, (2)°, (2)°, (2) A3, , , , K. The crystal structure is stabilized by weak intermolecular C–HO and N–HO hydrogen interactions.