W. Xue
2003
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Journal
Chinese Journal of Pharmaceuticals
Abstract
Sivelestat sodium was synthesized from glycine benzyl ester p -toluenesulfonate by condensation with 2-nitrobenzoyl chloride, and reduction to afford N -(2-aminobenzoyl)glycine benzyl ester, followed by condensation with p -pivaloyloxybenzenesulfonyl chloride, debenzylation and salt formation. The overall yield was 56.9%.