S. Juan
2007
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Journal
Chinese Journal of Pharmaceuticals
Abstract
Sodium ozagrel, an anti-thrombosis agent, was synthesized from ethyl 4-methyl cinnamate by bromination with NBS to give ethyl 4-bromomethyl cinnamate, which was condensed with imidazole in ionic liquid N-n- butylpyridinium tetrafluoroborate followed by hydrolysis with an overall yield of about 67%.